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Gut microbiome and gene editing projects share in $3 million research funding

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Gut microbiome and gene editing
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Gut microbiome and gene editing projects share in $3 million research funding

 

Dementia Australia

Exploring how the gut microbiome may be key to the early diagnosis and development of treatments for Alzheimer’s disease and combining gene editing technology with artificial intelligence are just two of the projects to receive funding from the Dementia Australia Research Foundation’s 2023 Grant Round.

The Dementia Australia Research Foundation today announced funding for 24 projects in the 2023 Grants Program, worth more than $3 million in total.

Macquarie University post-doctoral fellow Dr Pradeep Manuneedhi Cholan received the Race Against Dementia – Dementia Australia Research Foundation Post-Doctoral Fellowship to study how the gut microbiome impacts the progression of Alzheimer’s disease.

Established in 2020 by racing legend and Dementia Australia Patron Sir Jackie Stewart OBE’s Race Against Dementia charity and the Dementia Australia Research Foundation, the Fellowship supports early career researchers in the field of dementia prevention or treatment.

“The gut is often referred to as our ‘second brain’ as it can control our emotions, stress response and cognition. Previous research has shown that the metabolites produced by bacterial species in the gut can impact inflammation in the brain, which can either exacerbate or alleviate the progression of Alzheimer’s disease,” Dr Cholan said.

“What is not known is specifically how the metabolites produced by different types of gut bacteria can regulate the progression of Alzheimer’s disease which is what I will be focusing on with this project.

“If successful, this project will pave the way for the early diagnosis of Alzheimer’s disease and aid in the development of new drug treatments. It could also allow for better management of Alzheimer’s disease by analysing the gut composition of patients and providing them with lifestyle-based interventions tailored to their particular microbiome.”

Sir Jackie Stewart said Race Against Dementia prides itself on finding new ways of doing business.

“We are very pleased to welcome Pradeep to the team as his commitment and ingenuity are essential tools that will assist us to find new avenues for treatments to challenge dementia in the fullest sense,” Sir Jackie said.

Dr Caitlin Finney, from the Westmead Institute for Medical Research, will receive a Dementia Research Community Project Grant for a project that combines artificial intelligence and gene editing technology to develop better targeted treatments for Alzheimer’s disease.

“We know that genetic differences in our DNA might play a role in causing Alzheimer’s disease. Using a type of artificial intelligence called supervised machine learning, we have identified two genetic mutations that show up commonly in people living with late onset Alzheimer’s disease,” Dr Finney said.

“What this grant will enable us to do is to collect skin samples from people living with Alzheimer’s disease and use these cells to grow mini-brains in the lab. Using a gene editing technique called CRISPR-Cas9, we will be able to insert and remove the genetic mutations we have identified.

“This will allow us to learn new ways to keep our brains healthy as we get older. This knowledge can also help clinicians treat Alzheimer’s disease in a personalised way, where we correct the effects of DNA mutations with targeted treatments. If we find the real reasons why Alzheimer’s disease develops, we may even be able to prevent it from starting.”

Dementia Australia Research Foundation Chair Professor Graeme Samuel AC congratulated all successful 2023 grant recipients.

“The diversity of projects selected shows we have a very exciting future for dementia research,” Professor Samuel said.

“With dementia affecting almost 50 million people worldwide, research into dementia is now more urgent than ever.”

The Dementia Australia Research Foundation acknowledges the generosity of donors who contribute each and every year to support dementia research and the grants program. Since the Dementia Grants Program started in 2000, over $31 million in funding has supported more than 380 projects.

The full list of grant recipients is available here.

The Dementia Australia Research Foundation is the research arm of Dementia Australia, which provides funding to support new and emerging dementia researchers.

For support, please contact the National Dementia Helpline on 1800 100 500. An interpreter service is available. The National Dementia Helpline is funded by the Australian Government. People looking for information can also visit here.

 

For more National Australia News, visit here.

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Vape Laws Spark Opposition

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Vape Laws Spark Opposition

 

Queuing at local pharmacies is expected to become longer and more complex due to new laws permitting pharmacies to sell e-cigarettes, commonly known as vapes.

As of 1 July, pharmacies are the sole legal dispensers of nicotine-containing vapes. Initially, customers will need a prescription to purchase these products, but starting 1 October, adults will be able to buy them after a consultation with the pharmacist.

However, the new legislation has sparked significant opposition from many pharmacy chains and independent chemists. The Pharmacy Guild of Australia has strongly criticised the move, describing the expectation for pharmacists to retail vapes as “insulting.”

“Pharmacists are healthcare professionals, and community pharmacies do not want to supply this potentially harmful, highly addictive product without a prescription,” stated Anthony Tassone, the guild’s national vice-president. Tassone also emphasised that vaping products have not been approved by the Therapeutic Goods Administration (TGA) and no nicotine-containing vape is listed on the Australian Register of Therapeutic Goods.

The controversial laws were passed by Parliament following a compromise between Labor and the Greens. Beginning 1 October, pharmacists who opt to sell vapes will be able to provide them to customers aged 18 or over with proper ID but without requiring a prescription, as nicotine vapes will be reclassified from schedule 4 to schedule 3 of the poison’s standard. However, individuals under 18 will still need a prescription to purchase nicotine vapes.

The intent behind the new laws is to regulate the sale of nicotine vapes more strictly while making them accessible for adults who choose to use them. Despite this, the Pharmacy Guild remains critical, highlighting the health risks associated with vaping and the added responsibility placed on pharmacists to manage these products safely.

As the implementation date approaches, the debate within the healthcare community and among the public is likely to intensify, raising questions about the balance between accessibility and safety in the regulation of nicotine vapes.

 

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Onsite Pharmacists – Just What the Doctor Ordered

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Onsite Pharmacists – Just What the Doctor Ordered

 

The Aged Care Onsite Pharmacist (ACOP) program aims to revolutionise medication delivery in residential facilities by placing trained professionals directly on-site.

Addressing Medication Mismanagement

The mismanagement of medications, inconsistent safety procedures, and low vaccination rates in aged care homes have long been controversial. Health authorities are urging providers to increase vaccine rates, as the lives of residents and communities are at risk. Despite these pleas, the Royal Australian College of General Practitioners reported that 97 aged care facilities had COVID-19 vaccination rates below 10%. Additionally, 706 facilities reported less than 50% of their residents vaccinated against COVID, with the lowest coverage in various states including New South Wales, Queensland, South Australia, Tasmania, Victoria, and Western Australia.

The Role of Onsite Pharmacists

The Aged Care Royal Commission identified medication delivery as a crucial area for improvement in aged care homes, recommending the employment of allied health practitioners, including pharmacists. Responding to this, the Federal Government has allocated $333.7 million to fund the ACOP program. This initiative enables residential aged care providers to engage pharmacists through local pharmacies or direct employment. These pharmacists will deliver personalised medications, manage frequent medication reviews, and administer antipsychotic drugs and vaccinations.

Goals of the ACOP Program

The ACOP aims to:

  • Improve medication use and safety in aged care homes, particularly the use of high-risk medications.
  • Ensure continuity in medication management through regular reviews and prompt issue resolution.
  • Provide easy access to pharmaceutical advice for residents and staff.
  • Integrate on-site pharmacists with the healthcare team, including local GPs, nurses, and community pharmacies.
  • Enhance understanding and response to individual resident needs.

Support from the Pharmacy Guild of Australia

The initiative has garnered support from the Pharmacy Guild of Australia, recognising the potential to elevate the role of pharmacies. This program enables pharmacists not only to deliver medications and dose administration aids but also to provide quality use of medicines within the facility. A Pharmacy Guild spokesperson highlighted the additional services pharmacists can offer, such as vaccinations, as they begin to practice to their full scope. This will create further opportunities for community pharmacies to become significant providers of healthcare services to aged care facilities.

Funding Model

The ACOP funding model is divided into two tiers:

  • Tier 1: Community pharmacies receive payments to engage with specific residential aged care facilities.
  • Tier 2: Residential aged care facilities can claim up to $138,282 per year for the full-time equivalent employment of an on-site pharmacist.

This government-funded initiative promises to improve medication management and overall healthcare in aged care facilities, ensuring better health outcomes for residents.

 

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Foods That Can Help Reduce or Prevent Joint Pain

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Minimally processed, whole foods That Can Help Reduce or Prevent Joint Pain
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Foods That Can Help Reduce or Prevent Joint Pain

 

Minimally processed, whole foods — including brightly coloured fruits and vegetables, healthy fats, and lean proteins — may help relieve inflammation and other symptoms that lead to joint pain. Inflammation is a common cause of joint pain, often associated with arthritis and other joint conditions. Eating foods that help reduce inflammation may improve joint pain and offer additional health benefits, such as improved heart health.

Can Diet Help Reduce Joint Pain?

Research indicates that diet can significantly impact joint health. A survey of 217 people with rheumatoid arthritis (RA) found that 24% reported their diet affected their symptoms. A 2023 study on osteoarthritis supports the idea that certain diet patterns can improve joint symptoms. Diets high in nuts, legumes, fruits, vegetables, and seafood, which contain anti-inflammatory properties like antioxidants and phytochemicals, may help reduce joint pain.

Beneficial Foods for Joint Pain

Incorporating anti-inflammatory foods into your diet can help reduce joint pain and slow disease activity. Beneficial foods include:

  • Nuts: Rich in healthy fats and antioxidants.
  • Legumes: High in fibre and protein, reducing inflammation.
  • Fruits and Vegetables: Packed with vitamins, minerals, and antioxidants.
  • Seafood: Especially fatty fish like salmon and mackerel, high in omega-3 fatty acids.

Foods to Avoid

To manage joint pain, limit or avoid processed foods, trans fats, and added sugars. A nutrient-rich diet can also help maintain a moderate weight, reducing strain on the joints.

Popular Diets for Joint Pain

The Mediterranean Diet

Emphasises fruits, vegetables, whole grains, legumes, and healthy fats, with moderate seafood and poultry, and limited dairy and red meat. Associated with reduced inflammation and improved joint health.

The DASH Diet

Includes fruits, vegetables, fish, poultry, nuts, whole grains, and low-fat dairy while restricting salt, sugar, fats, and red meat. May help improve and reduce the risk of gout, a type of arthritis that causes joint pain.

Conclusion

Incorporating a variety of nutrient-rich, anti-inflammatory foods into your diet can help manage and prevent joint pain. Following dietary patterns like the Mediterranean or DASH diets may offer comprehensive benefits for joint health and overall well-being.

 

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