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First-Ever Clinical Trial of mRNA Cancer Vaccine Shows Promise Against Brain Cancer

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First-Ever Clinical Trial of mRNA Cancer Vaccine Shows Promise Against Brain Cancer

 

A groundbreaking clinical trial at the University of Florida has demonstrated promising results for an mRNA cancer vaccine targeting brain cancer cells. This innovative approach has shown potential in activating the immune system to combat these aggressive tumours.

In the trial, genetic material called RNA was extracted from the tumours of four patients, amplified, and then modified to mimic a dangerous virus. This modified RNA was then reintroduced into the bloodstream, triggering a robust immune response.

Senior author and vaccine pioneer Elias Sayour explained the personalised nature of the vaccines.

“Instead of us injecting single particles, we’re injecting clusters of particles that are wrapping around each other like onions, like a bag full of onions,” Sayour said. “And the reason we’ve done that in the context of cancer is these clusters alert the immune system in a much more profound way than single particles would.”

Sayour highlighted the rapid and significant immune response observed in the trial. “In less than 48 hours, we could see these tumours shifting from what we refer to as ‘cold’—with very few immune cells and a silenced immune response—to ‘hot,’ with a very active immune response,” he said. “This quick activation of the early immune system is critical for unlocking the later effects of the immune response.”

Patients participating in the trial lived longer than expected, although it is too early to determine the full clinical effects of the vaccine. The current standard treatments for brain cancers like glioblastoma include surgery, radiation, and chemotherapy.

Next Steps for the Vaccine

The next phase of the vaccine development involves expanding the clinical trial to include up to 24 adult and paediatric patients. This expansion aims to further validate the vaccine’s efficacy and safety, potentially leading to a new standard of care for brain cancer patients.

The promising results from this initial trial offer hope for a new, effective treatment strategy against one of the most challenging forms of cancer. If further trials confirm these findings, the mRNA cancer vaccine could revolutionise the way brain cancer is treated, providing personalised and highly targeted therapy.

 

For more health news, click here.

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Northern Rivers health workers up for awards

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Northern Rivers health workers up for awards

By Tim Howard

Staff from Northern NSW Local Health District have been named as finalists for the 2024 NSW Health Awards for their extraordinary efforts to improve the NSW public health system.

Now in its 26th year, the awards acknowledge the personalised, sustainable, and digitally enabled programs that contribute to the wellbeing of patients and the community.

The Rheumatic Heart Disease Project and the Rural Paediatric Complex Care Coordination Project are among 42 finalists from across the state competing for the Excellence in Aboriginal Healthcare Award and Health Innovation Award, respectively.

The Rheumatic Heart Disease Project  aims to address the significant public health issue of Acute Rheumatic Fever (ARF) and RHD among Aboriginal communities in Northern NSW.

The project was led by Aboriginal Health Nurse Manager Emma-Jane Davies and supported by Robin Auld, Sally Adams and Daniel Ashton, with valuable advice and advocacy from Aboriginal Medical Service partners, in particular Scott Monaghan from Bulgarr Ngaru Medical Aboriginal Corporation.

The Rural Paediatric Complex Care Coordination Project improves care coordination for regional NSW children, reduces family costs and disruptions, and improves outcomes for families in regional NSW.

This is a joint project with Northern NSW, Murrumbidgee, Southern NSW and Western NSW local health districts, together with the Sydney Children’s Hospitals Network.

Rheumatic Heart Disease Project team members, from left, Tracy Bradshaw (Aboriginal Health Worker, Chronic Care for Aboriginal People), Sasha Harrington (Aboriginal Health Engagement and Governance Manage), Daniel Ashton (Aboriginal Health Performance and Project Analyst), Emma-Jane Davies (Nurse Manager Aboriginal Health) and Kirsty Glanville (executive director Aboriginal Health, NNSWLHD).

Northern NSW Local Health District also partnered with Justice Health, the Forensic Mental Health Network, NSW Health Pathology and NSW Health in the NSW Dried Blood Spot Validation Study that has been named a finalist in the Health Innovation Award.

This project is the first of its kind, and aims to make dried blood spot testing a standard diagnostic tool and, if successful, will change how testing is offered for people at risk of hepatitis C.

NNSWLHD chief executive Tracey Maisey praised the achievements of local finalists who have been recognised for their passion and commitment.

“I am thrilled to congratulate our NNSWLHD staff on having their outstanding contributions to our health system recognised,” Ms Maisey said.

NSW Health secretary Susan Pearce AM said it is really exciting to celebrate the people and teams who are enriching health in millions of ways every day.

“These awards are a chance to recognise our incredible healthcare staff and volunteers, across the public health system,” Ms Pearce said.

“I congratulate the finalists, but I also want to acknowledge the work being done across the system every day, by our teams of doctors, nurses, midwives, allied health and support staff.”

NSW Health received 186 nominations across the 12 award categories.

The finalists and winners will be celebrated at the NSW Health Awards ceremony, which will be held on Thursday, October 24 at the International Convention Centre in Sydney.

It will also be livestreamed from 6pm.

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Forty per cent of women from Northern NSW overdue for breast screening

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Forty per cent of women from Northern NSW overdue for breast screening

By Ian Rogers

This Breast Cancer Awareness Month, women aged 50-74 in the Northern NSW Local Health District are being encouraged to schedule a free mammogram, as over 40% (44.7%) of women in the region are overdue for their biannual breast cancer screening.

Patrick Magee, Acting Director of BreastScreen NSW’s North Coast Screening and Assessment Service, emphasized that with around 300 local women expected to be diagnosed with breast cancer this year, now is the time to book a free, potentially life-saving breast screen.

“For women aged 50-74, a breast screen every two years is still the best way to detect breast cancer early – before it can be seen or felt,” Mr Magee said.

“If you’re aged 50 – 74, make breast screening a priority. It only takes 20 minutes and no doctor’s referral is needed.”

This Breast Cancer Awareness Month, BreastScreen NSW is urging women to “Be A Friend, Tell A Friend” about the importance of regular mammograms. The campaign encourages women to spread the word through conversation and social media, reminding friends, family, and colleagues to prioritize breast cancer screenings.

Professor Tracey O’Brien AM, NSW Chief Cancer Officer and CEO of the Cancer Institute NSW, highlighted that early detection is key: when breast cancer is found in its earliest stages, the five-year survival rate is 98 percent. However, this drops to 43.9 percent when the cancer has spread to other organs.

“More than 6500 women in NSW are expected to receive a breast cancer diagnosis this year, and 1,000 women are expected to lose their lives to the disease in 2024, so we need to do everything we can to support women and encourage them to book in a life-saving breast screen,” Professor O’Brien said.

“Early detection not only significantly increases a person’s chance of survival it can also greatly reduce the need for invasive treatment like a mastectomy.

“I know how hard it can be to block out time for yourself. Unfortunately, breast cancer doesn’t wait, so I encourage all eligible women to stop and put themselves first – for themselves and their family.”

Breast cancer is the most common cancer among women, with age and gender being the biggest risk factors—family history is not the primary concern.

Women aged 50-74 are advised to have a breast screen every two years. BreastScreen NSW also recommends that Aboriginal women begin screening at 40, as research indicates they are more likely to be diagnosed at a younger age, with more advanced cancer at diagnosis and poorer survival rates compared to the general female population.

Any woman who notices changes in her breasts, such as a lump, should consult her doctor immediately.

For more information and to make an appointment at a local BreastScreen NSW clinic or mobile van, call 13 20 50 or book online at www.breastscreen.nsw.gov.au.

For more information about the Be A Friend Tell A Friend promotion visit here.

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Breast Cancer Awareness Month

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Breast Cancer Awareness Month

The Honorable Aileen MacDonald has reminded the public that October is Breast Cancer Awareness Month.

Ms. MacDonald emphasised the importance of supporting the National Breast Cancer Foundation during this time, as breast cancer remains the second most commonly diagnosed cancer in Australia, claiming the lives of nine people each day.

“The aim of Breast Cancer Awareness Month is to shine a light on the devastating impact breast cancer has on thousands of Australians each day,” Ms MacDonald said.

“The statistics are alarming. Every year more than 21,000 people in Australia, including around 200 men, will be diagnosed with breast cancer,” she said.

“It saddens me that every year more than 3,300 people in Australia, including 33 men, will die from breast cancer.”

Ms. MacDonald encouraged everyone to undergo screenings, as early detection significantly improves the chances of successful treatment for breast cancer confined to the breast.

“If you experience any symptoms such as lumps, dimples, discharge or discolouration, head to your doctor for further examination,” she said.

For further information Ms MacDonald said visit the National Breast Cancer Foundation website.

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