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Health News

New development for hormone-free male contraceptive pill

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New development for hormone-free male contraceptive pill

MONASH UNIVERSITY

EMBARGOED until FRIDAY JULY 29, 7:30 AEST

A new study led by a team of Monash researchers working to develop a male contraceptive pill has identified that stinging nettle leaf extract has the potential to block a protein that controls the movement of sperm.

The discovery is an incremental yet important advance for the research group, led by Dr Sab Ventura from the Monash Institute of Pharmaceutical Sciences, who have previously shown that male infertility could be genetically achieved by simultaneously deleting two proteins that trigger the transport of sperm – α1A-adrenoceptor and P2X1-purinoceptor – but without affecting the long-term viability of sperm or sexual and general health.

 

The study, published in PLOS ONE, identified that stinging nettle leaf extract contains a component that could orally inhibit one of the two proteins, P2X1-purinoceptor. Dr Ventura said that this is an exciting step forward to show that the teams’ biological mechanism for male contraception is orally viable.

“The primary aim of this research was to investigate the activity of a commercially available stinging nettle extract as an inhibitor of the P2X1-purinoceptor target, and to determine its pharmacological effect,” said Dr Ventura.

“In this study we were able to conclude that stinging nettle leaf extract reduces contractility of urinary and genital smooth muscle by acting as a P2X1-purinoceptor antagonist, and that blocking sperm transport through pharmacological blockade of P2X1-purinoceptors via oral administration is an effective and convenient biological strategy for male contraception.”

The next step for this research is to isolate the bioactive component of this extract or identify a similar compound suitable for chemical optimization to use as a male contraceptive.

At the moment the options for male contraception include only condoms and vasectomy, with the burden of preventing pregnancy largely and unevenly falling on women or people with a uterus.

“Unfortunately there has been a widespread perception that birth control is a women’s problem rather than a men’s problem,” said Dr Ventura.

“However research led by the Male Contraceptive Initiative shows that the majority of men are willing to take control over contraception – we just need to give them the opportunity to do so.”

To read the full article entitled Aqueous extracts of Urtica dioica (stinging nettle) leaf contain a P2-purinoceptor antagonist—Implications for male fertility visit: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0271735

 

 

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Vape Laws Spark Opposition

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Vape Laws Spark Opposition

 

Queuing at local pharmacies is expected to become longer and more complex due to new laws permitting pharmacies to sell e-cigarettes, commonly known as vapes.

As of 1 July, pharmacies are the sole legal dispensers of nicotine-containing vapes. Initially, customers will need a prescription to purchase these products, but starting 1 October, adults will be able to buy them after a consultation with the pharmacist.

However, the new legislation has sparked significant opposition from many pharmacy chains and independent chemists. The Pharmacy Guild of Australia has strongly criticised the move, describing the expectation for pharmacists to retail vapes as “insulting.”

“Pharmacists are healthcare professionals, and community pharmacies do not want to supply this potentially harmful, highly addictive product without a prescription,” stated Anthony Tassone, the guild’s national vice-president. Tassone also emphasised that vaping products have not been approved by the Therapeutic Goods Administration (TGA) and no nicotine-containing vape is listed on the Australian Register of Therapeutic Goods.

The controversial laws were passed by Parliament following a compromise between Labor and the Greens. Beginning 1 October, pharmacists who opt to sell vapes will be able to provide them to customers aged 18 or over with proper ID but without requiring a prescription, as nicotine vapes will be reclassified from schedule 4 to schedule 3 of the poison’s standard. However, individuals under 18 will still need a prescription to purchase nicotine vapes.

The intent behind the new laws is to regulate the sale of nicotine vapes more strictly while making them accessible for adults who choose to use them. Despite this, the Pharmacy Guild remains critical, highlighting the health risks associated with vaping and the added responsibility placed on pharmacists to manage these products safely.

As the implementation date approaches, the debate within the healthcare community and among the public is likely to intensify, raising questions about the balance between accessibility and safety in the regulation of nicotine vapes.

 

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Onsite Pharmacists – Just What the Doctor Ordered

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Onsite Pharmacists – Just What the Doctor Ordered

 

The Aged Care Onsite Pharmacist (ACOP) program aims to revolutionise medication delivery in residential facilities by placing trained professionals directly on-site.

Addressing Medication Mismanagement

The mismanagement of medications, inconsistent safety procedures, and low vaccination rates in aged care homes have long been controversial. Health authorities are urging providers to increase vaccine rates, as the lives of residents and communities are at risk. Despite these pleas, the Royal Australian College of General Practitioners reported that 97 aged care facilities had COVID-19 vaccination rates below 10%. Additionally, 706 facilities reported less than 50% of their residents vaccinated against COVID, with the lowest coverage in various states including New South Wales, Queensland, South Australia, Tasmania, Victoria, and Western Australia.

The Role of Onsite Pharmacists

The Aged Care Royal Commission identified medication delivery as a crucial area for improvement in aged care homes, recommending the employment of allied health practitioners, including pharmacists. Responding to this, the Federal Government has allocated $333.7 million to fund the ACOP program. This initiative enables residential aged care providers to engage pharmacists through local pharmacies or direct employment. These pharmacists will deliver personalised medications, manage frequent medication reviews, and administer antipsychotic drugs and vaccinations.

Goals of the ACOP Program

The ACOP aims to:

  • Improve medication use and safety in aged care homes, particularly the use of high-risk medications.
  • Ensure continuity in medication management through regular reviews and prompt issue resolution.
  • Provide easy access to pharmaceutical advice for residents and staff.
  • Integrate on-site pharmacists with the healthcare team, including local GPs, nurses, and community pharmacies.
  • Enhance understanding and response to individual resident needs.

Support from the Pharmacy Guild of Australia

The initiative has garnered support from the Pharmacy Guild of Australia, recognising the potential to elevate the role of pharmacies. This program enables pharmacists not only to deliver medications and dose administration aids but also to provide quality use of medicines within the facility. A Pharmacy Guild spokesperson highlighted the additional services pharmacists can offer, such as vaccinations, as they begin to practice to their full scope. This will create further opportunities for community pharmacies to become significant providers of healthcare services to aged care facilities.

Funding Model

The ACOP funding model is divided into two tiers:

  • Tier 1: Community pharmacies receive payments to engage with specific residential aged care facilities.
  • Tier 2: Residential aged care facilities can claim up to $138,282 per year for the full-time equivalent employment of an on-site pharmacist.

This government-funded initiative promises to improve medication management and overall healthcare in aged care facilities, ensuring better health outcomes for residents.

 

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Foods That Can Help Reduce or Prevent Joint Pain

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Minimally processed, whole foods That Can Help Reduce or Prevent Joint Pain
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Foods That Can Help Reduce or Prevent Joint Pain

 

Minimally processed, whole foods — including brightly coloured fruits and vegetables, healthy fats, and lean proteins — may help relieve inflammation and other symptoms that lead to joint pain. Inflammation is a common cause of joint pain, often associated with arthritis and other joint conditions. Eating foods that help reduce inflammation may improve joint pain and offer additional health benefits, such as improved heart health.

Can Diet Help Reduce Joint Pain?

Research indicates that diet can significantly impact joint health. A survey of 217 people with rheumatoid arthritis (RA) found that 24% reported their diet affected their symptoms. A 2023 study on osteoarthritis supports the idea that certain diet patterns can improve joint symptoms. Diets high in nuts, legumes, fruits, vegetables, and seafood, which contain anti-inflammatory properties like antioxidants and phytochemicals, may help reduce joint pain.

Beneficial Foods for Joint Pain

Incorporating anti-inflammatory foods into your diet can help reduce joint pain and slow disease activity. Beneficial foods include:

  • Nuts: Rich in healthy fats and antioxidants.
  • Legumes: High in fibre and protein, reducing inflammation.
  • Fruits and Vegetables: Packed with vitamins, minerals, and antioxidants.
  • Seafood: Especially fatty fish like salmon and mackerel, high in omega-3 fatty acids.

Foods to Avoid

To manage joint pain, limit or avoid processed foods, trans fats, and added sugars. A nutrient-rich diet can also help maintain a moderate weight, reducing strain on the joints.

Popular Diets for Joint Pain

The Mediterranean Diet

Emphasises fruits, vegetables, whole grains, legumes, and healthy fats, with moderate seafood and poultry, and limited dairy and red meat. Associated with reduced inflammation and improved joint health.

The DASH Diet

Includes fruits, vegetables, fish, poultry, nuts, whole grains, and low-fat dairy while restricting salt, sugar, fats, and red meat. May help improve and reduce the risk of gout, a type of arthritis that causes joint pain.

Conclusion

Incorporating a variety of nutrient-rich, anti-inflammatory foods into your diet can help manage and prevent joint pain. Following dietary patterns like the Mediterranean or DASH diets may offer comprehensive benefits for joint health and overall well-being.

 

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